(9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one and Tuberculosis--Pulmonary

Topics: Azathioprine; Beclomethasone; Diagnosis, Differential; Glucocorticoids; Humans; Immunosuppressive Agents; Lung Diseases; Recurrence; Sarcoidosis; Triamcinolone Acetonide; Tuberculosis, Pulmonary

Inhaled beclomethasone dipropionate (BDP) has been used with few side-effects in the treatment of bronchial asthma for 2 decades. Until now the manifestation of tuberculosis (TB) in patients on inhaled BDP has not been reported. Eight patients with allergic asthma, of a total of 548 asthmatics (1.46%) seen over a 2-year period, developed active TB following the use of inhaled BDP. All were sputum-positive for acid-fast bacilli (AFB) on smear and/or culture, all responded well to a combination of anti-TB drugs, and none showed evidence of immunological or pituitary-adrenal suppression. Two patients agreed to a repeat administration of BDP; both developed TB again within 2 weeks and are again on anti-TB treatment.

Topics: Administration, Inhalation; Adolescent; Adult; Antitubercular Agents; Asthma; Beclomethasone; Female; Humans; Male; Mycobacterium tuberculosis; Tuberculosis, Pulmonary

Topics: Alveolitis, Extrinsic Allergic; Asthma; Beclomethasone; Bronchitis; Humans; Hydrocortisone; Lung Neoplasms; Prednisolone; Pulmonary Eosinophilia; Pulmonary Fibrosis; Respiratory Tract Diseases; Sarcoidosis; Steroids; Tuberculosis, Pulmonary

Topics: Animals; Beclomethasone; Guinea Pigs; Lymphocyte Activation; Rosette Formation; T-Lymphocytes; Tuberculosis, Pulmonary

A patient who was receiving a steroid aerosol for treatment of asthma developed clinical pulmonary tuberculosis. Continued administration of the steroid aerosol along with antituberculosis chemotherapy did not adversely influence healing of the pulmonary lesion.

Topics: Adult; Aerosols; Asthma; Beclomethasone; Dexamethasone; Humans; Isoniazid; Tuberculosis, Pulmonary